Thyroid Disorders
نویسندگان
چکیده
In the last decade, discoveries in molecular biology field have allowed new insight into the genes involved in the development of AITD. At least six susceptibility genes whose variants have been associated with AITD were identified: HLA-DR, CD40, CTLA-4, PTPN22, thyroglobulin (Tg), and thyroid stimulating hormone (TSH) receptor. Genetic susceptibility accounts for 70 % risk for disease that, once combined with environmental factors, play a crucial role in the initiation and progression of the disease. Studies with immunoglobulin (Ig)-G4 autoantibody levels in juvenile thyroid disease patients showed evidence of heritability.
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تاریخ انتشار 2015